IBD Therapeutics Incubator: Request for Proposals
The Crohn’s & Colitis Foundation (Foundation) is dedicated to addressing the unmet needs of patients with inflammatory bowel diseases (IBD). The goal of this
Under the IBD Therapeutics Incubator program, the Foundation will partner with academic researchers and a specialized contract research organization (CRO) to provide drug discovery and development resources to generate a drug discovery preclinical package, that can be further advanced by larger venture investors and pharmaceutical/biotech companies, into new therapeutic products to address medical unmet needs of patients with Crohn’s disease and ulcerative colitis.
Specifically, this incubator-like mechanism enables the advancement of novel and validated drug targets discovered in academia and for which academic researchers lack adequate expertise and resources for drug discovery and development. In this therapeutics incubator model, the expert drug discovery and development staff of the Crohn’s & Colitis Foundation will take an active role in designing and leading the project(s), in collaboration with the academic applicant(s) and CRO scientists. The R&D work will be mainly performed by the CRO, and if required, some of the research activities can be performed by the academic partner at their facility.
For detailed information regarding the program scope, eligibility, policies, and application instructions click here to download the full RFP document. The proposal should align with the scope of the RFP (section 2). In summary, proposed drug targets should meet most if not all the following criteria:
We anticipate investing up to $1,500,000 over a three-year period per project. While most of the budget will be used to fund activities at the selected CRO, in some instances funds could go to the academic investigator to support research activities not available at the CRO.
For further information about IBD unmet needs that can be addressed by new research-based products, refer to our latest publication: Honig G, Larkin PB, Heller C, Hurtado-Lorenzo A. (2021). Research-Based Product Innovation to Address Critical Unmet Needs of Patients with Inflammatory Bowel Diseases. Inflamm Bowel Dis. 27(Suppl 2): S1-S16.
For an infographic of the IBD Therapeutics Incubator, fundamentals click here.
Program information and application forms can be accessed and must be submitted through proposalCENTRAL.
Deadline for proposal submission: October 3, 2022.
Jean-Luc Tran, Director, IBD Therapeutics Incubator and Dr. Andrés Hurtado-Lorenzo, VP Translational Research & IBD Ventures