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Document
Accelerating Drug Discovery for Alzheimer’s Disease: Best Practices for Preclinical Animal Studies

The Alzheimers Drug Discovery Foundation (ADDF) partnered with Charles River to convene a panel of academic, industry and government scientists to make recommendations on best practices for animal studies testing investigational ...

 

 

Charles River

 

Presenter: Charles River

Video
Can we Treat MS?

Current therapies for MS, an autoimmune neuroinflammatory disease, target the immune part of the disease but current drug discovery efforts focus on treating and even reversing progressive disease. Check out the recent discussion on new research and ...

 

 

Charles River

 

Presenter: Antti Nurmi, PhD, Director of Science

PPT
Case Study: The Discovery of Telaprevir (VX-950, Incivek®) for the treatment of Hepatitis C

This Case study shows the drug discovery process of Telaprevir for Hepatitis. IT discusses the background of Hepatitis, and the basic information on Hepatitis C, Preclinical studies, Clinical studies, critical findings, timeline to approval and the f...

 

Brain Science Institute NeuroTranslational Drug Discovery Program

 

Johns Hopkins University

 

Presenter: Dana Ferraris, Ph.D., M.B.A.

PPT
In Vivo Pharmacokinetics

A lecture discussing In vivo Pharmacokinetics including commonly used animals, routes of administration, blood sampling, bioanalysis, pharmacokinetics parameters, and Pharmacokinetics/Pharmacodynamics. This is the sixth lecture in a 15 week course, ⮮.

 

Brain Science Institute NeuroTranslational Drug Discovery Program

 

Johns Hopkins University

 

Presenter: Takashi Tsukamoto, Ph.D

PPT
In Vivo Pharmacology

A lecture discussing In vivo Pharmacology, the definition, rules and ethics governing animal experimentation, history, shortcomings, use in drug discovery, study design considerations, and specific examples of some disease models.This is the eighth l...

 

Brain Science Institute NeuroTranslational Drug Discovery Program

 

Johns Hopkins University

 

Presenter: Krystyna Wozniak, Ph.D.

PPT
It’s all about dose…. Toxicology in Drug Discovery and Development

Nonclinical toxicology studies are critical during drug development due to the scientific need and regulatory requirement to collect information to define the toxicity profile and provide an evaluation of the relationship of dose and exposure to toxi...

 

 

Ironwood Pharmaceticals

 

Presenter: Adaline C. Smith, PhD, DABT

Video
Reduced Cognitive Flexibility and Altered Metabolic Profile in the Prefrontal Cortex of CVN mice

In this study, the well-characterized Alzheimer's disease CVN mouse model is analyzed for cognitive flexibility using touchscreen testing. The study showed that CVN mice made more errors and needed more correction trials compared to wild-type mice in...

 

 

Charles River

 

Presenter: Maksym Kopanitsa, PhD