University of Kansas High-Throughput Screening Laboratory

Therapeutic Approaches: Small Molecules

Therapeutic Areas of Expertise: Cardiology, Immunology, Infectious Diseases, Metabolic Disorders, Neurological Disorders, Oncology

Center/Program Highlights: High throughput screening of large libraries of compounds has the potential to identify novel chemical entities that target a biological system of interest. To have this technology available to biomedical researchers in Kansas and beyond, the HTS laboratory was established in 2002 at the University of Kansas with support from an NIH COBRE grant, the State of Kansas and the University, and it is a shared resource for the University's Cancer Center. KU-HTSL provides services in advancing drug discovery research initiatives, as well as assistance in preparing grant applications. HTS personnel have extensive experience in executing biochemical, cell-based, siRNA as well as high content screening campaigns against a plethora of target classes. We also serve as a portal for all that the University of Kansas has to offer in supporting drug discovery efforts. We strive to establish an enduring relationship with our collaborators in addressing their drug discovery needs pertaining to target identification and validation, assay development, high throughput screening, hit confirmation, data mining and medicinal chemistry to facilitate hit to lead development. KU-HTSL further leverages the strengths of the KU core facilities (protein production, flow cytometry, imaging, chemo-and bio informatics, medicinal chemistry, etc) and the KU Medical Center's Office of Therapeutics, Discovery and Development to advance your lead discovery research. Most importantly, the HTSC infrastructure is built with a pharma perspective in accelerating drug discovery efforts

Sources of Funding: Federal/State, Philanthropy, Industry Partnerships, University

Website

Institutional Affiliation(s): University of Kansas, Lawrence University of Kansas Medical Center, Kansas City

Address:
Structural Biology Center
2034 Becker Drive
Lawrence
Kansas, 66047
United States

Center/Program Start Date: 2002

Number of Employees: 7